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MAINTENANCE TREATMENT FOR CERTAIN PATIENTS WITH ADVANCED UROTHELIAL CARCINOMA (UC)

BAVENCIO® (avelumab) is a prescription medicine used to treat a type of cancer in the bladder or urinary tract called urothelial carcinoma (UC) when it has spread or cannot be removed by surgery (advanced UC). BAVENCIO may be used as maintenance treatment when your cancer has responded or stabilized after you have received platinum-containing chemotherapy as your first treatment.

It is not known if BAVENCIO is safe and effective in children.

Support for eligible patients prescribed BAVENCIO® (avelumab)

CoverOne® provides patient access and reimbursement support services.

We recognize that each patient’s situation is different, and are dedicated to helping eligible BAVENCIO patients one at a time.

Please contact us at 1-844-8COVER1 if you have any questions.

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1-844-8COVER1
(1-844-826-8371)

Monday—Friday
8:00 AM—8:00 PM ET

Helpful Questions & Answers

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BAVENCIO® (avelumab) is a medicine that may treat certain cancers by working with your immune system. BAVENCIO can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death.

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with BAVENCIO. Your healthcare provider may treat you with corticosteroids or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with BAVENCIO if you have severe side effects.

BAVENCIO can cause serious side effects. Call or see your healthcare provider right away if you get any new or worsening signs or symptoms, including:

Lung problems (pneumonitis)—signs and symptoms may include:

  • new or worsening cough
  • shortness of breath
  • chest pain

Liver problems, including hepatitis-signs and symptoms may include:

  • yellowing of your skin or the whites of your eyes
  • severe nausea or vomiting
  • pain on the right side of your stomach area (abdomen)
  • drowsiness
  • dark urine (tea colored)
  • bleeding or bruising more easily than normal

Intestinal problems(colitis))-signs and symptoms may include:

  • diarrhea (loose stools) or more bowel movements than usual
  • blood in your stools or dark, tarry, sticky stools
  • severe stomach area (abdomen) pain or tenderness

Hormone gland problems(especially the adrenal glands, thyroid, and pancreas)-signs and symptoms that your hormone glands are not working properly may include:

  • rapid heartbeat
  • increased sweating
  • extreme tiredness
  • weight gain or weight loss
  • feeling more hungry or thirsty than usual
  • hair loss
  • changes in mood or behavior, such as irritability or forgetfulness
  • constipation
  • your voice getting deeper
  • very low blood pressure
  • urinating more often than usual
  • dizziness or fainting
  • nausea or vomiting
  • stomach area (abdomen) pain
  • feeling cold

Kidney problems, including nephritis-signs and symptoms may include:

  • decrease in your amount of urine
  • blood in your urine
  • swelling of your ankles
  • loss of appetite

Problems in other organs-signs and symptoms may include:

  • severe muscle weakness
  • severe or persistent muscle or joint pains
  • chest pain and tightness
  • skin rash, blisters, or peeling
  • changes in heartbeat, such as beating fast, seeming to skip a beat, or a pounding sensation
  • tiredness, sleepiness
  • swelling of the feet and legs
  • dizziness or fainting
  • fever, flu-like symptoms
  • changes in eyesight

Severe infusion reactions-signs and symptoms may include:

  • chills or shaking
  • hives
  • flushing
  • shortness of breath or wheezing
  • low blood pressure
  • fever
  • back pain
  • stomach area (abdomen) pain

BAVENCIO is a prescription medicine used to treat:

  • a type of cancer in the bladder or urinary tract called urothelial carcinoma (UC) when it has spread or cannot be removed by surgery (advanced UC). BAVENCIO may be used:
    • as maintenance treatment when your cancer has responded or stabilized after you have received platinum-containing chemotherapy as your first treatment

It is not known if BAVENCIO is safe and effective in children under the age of 12.

Before you receive BAVENCIO, tell your healthcare provider about all of your medical conditions, including if you:

  • have immune system problems such as Crohn’s disease or ulcerative colitis
  • have had an organ transplant
  • have lung or breathing problems
  • have liver or kidney problems
  • have diabetes
  • have heart problems or high blood pressure
  • have a high cholesterol level in your blood
  • are pregnant or plan to become pregnant. BAVENCIO can harm your unborn baby. If you are able to become pregnant, you should use an effective method of birth control during your treatment and for at least 1 month after the last dose of BAVENCIO
  • are breastfeeding or plan to breastfeed. It is not known if BAVENCIO passes into your breast milk. Do not breastfeed during treatment and for at least 1 month after the final dose of BAVENCIO

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Your healthcare provider will give you BAVENCIO into your vein through an intravenous (IV) line over 60 minutes

  • BAVENCIO is usually given every 2 weeks
  • Your healthcare provider will give you medicines before the first 4 infusions and then as needed to help reduce infusion reactions
  • Your healthcare provider will decide how many treatments you need
  • Your healthcare provider will do blood tests to check you for certain side effects
  • If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of BAVENCIO as maintenance treatment in people with UC whose cancer responded or stabilized after platinum-containing chemotherapy as first treatment include:

  • feeling tired
  • urinary tract infection
  • muscle and bone pain
  • rash

BAVENCIO can cause serious side effects:

  • Go to “What is the most important information I should know about BAVENCIO?” on top of this page

These are not all the possible side effects of BAVENCIO. Ask your healthcare provider or pharmacist for more information. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.